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Journal of Chemistry
Volume 2013, Article ID 727136, 4 pages
Research Article

A New Pentacyclic Triterpene from Humata tyermanni Moore with the Inhibitory Activities against LPS-Induced NO Production in RAW264.7 Macrophages

1Department of Chemistry, Jinan University, Guangzhou 510632, China
2Shenzhen Guangming New District Environmental Monitoring Station, Shenzhen Guangming City Construction Bureau, Shenzhen 518107, China
3Department of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou 510632, China

Received 8 April 2012; Accepted 23 May 2012

Academic Editor: Mohammad El-Shahawi

Copyright © 2013 Lei Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


One new pentacyclic triterpene, hopane-22 (29)-en-24ol (2), with five known hopane-type pentacyclic triterpene compounds: hop-22(29)-ene (1), adiantone (3), 22-hydroxyhopane (4), 6α, 22-dihydroxyhopane (5), and 17(21)-hopene (6) were isolated from Humata tyermanni Moore. The structure of compound 2 was elucidated on the basis of its 1D and 2D NMR spectral analysis. All these compounds were evaluated for their inhibitory activities of LPS-induced nitric oxide (NO) production in RAW264.7 macrophages.