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Journal of Chemistry
Volume 2013 (2013), Article ID 741953, 9 pages
Research Article

Ultrasonication-Induced Synthesis and Antimicrobial Evaluation of Some Multifluorinated Pyrazolone Derivatives

1P. G. Department of Chemistry and Research Centre, Padmashri Vikhe Patil College, Pravaranagar, Ahmednagar 413713, India
2Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar 414001, India

Received 6 June 2012; Revised 6 August 2012; Accepted 28 August 2012

Academic Editor: Qing Li

Copyright © 2013 Anil Gadhave et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of novel fluorine containing pyrazole-pyrazolone (4a–j) and chromone-pyrazolone (5a–i) was synthesized from multifluorinated pyrazolone by the Knoevenagel condensation reaction. All compounds were synthesized by conventional heating as well as ultrasound irradiation technique. It was found that ultrasonication method was more efficient than conventional heating method. The newly synthesized compounds were subjected for in vitro antimicrobial screening against four bacterial pathogens, namely, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and Pseudomonas aeruginosa and three fungal pathogens Candida albicans, Aspergillus niger, and Aspergillus clavatus, using broth microdilution (MIC) method (CLSI guidelines). Among them, some compounds exhibited promising antibacterial activity against the tested strains. All synthesized compounds were characterized by IR, 1H-NMR, mass, and elemental analysis.