Ultrasonication-Induced Synthesis and Antimicrobial Evaluation of Some Multifluorinated Pyrazolone Derivatives

Table 1

Physical data of synthesized pyrazole-pyrazolone (4a–j).

Compound	R	R1	M.P. (°C)	Conventional method		Ultrasound method
				Time (min)	Yield (%)	Time (min)	Yield (%)
4a	Propyl	C6H5	151-152	60	75	16	90
4b	Propyl	4-FC6H4	179-180	60	71	15	91
4c	Propyl	4-MeC6H4	192-193	60	69	18	88
4d	Propyl	4-ClC6H4	159-160	60	73	16	85
4e	Propyl	2-Thienyl	149-150	60	66	19	90
4f	CF3	C6H5	237-238	60	78	21	86
4g	CF3	4-FC6H4	235-236	60	74	19	93
4h	CF3	4-MeC6H4	253-254	60	71	18	89
4i	CF3	4-ClC6H4	216-217	60	76	17	94
4j	CF3	2-Thienyl	215-216	60	69	16	90