Ultrasonication-Induced Synthesis and Antimicrobial Evaluation of Some Multifluorinated Pyrazolone Derivatives

Table 2

Physical data of synthesized chromone-pyrazolone (5a–i).

Compound	R	R1	R2	R3	M. P. (°C)	Conventional method		Ultrasound method
						Time (min)	Yield (%)	Time (min)	Yield (%)
5a	Propyl	H	H	H	144-145	60	70	14	81
5b	Propyl	H	H	Me	146-147	60	68	16	80
5c	Propyl	Cl	H	Cl	194-195	60	69	13	82
5d	Propyl	H	H	Cl	166-167	60	72	17	78
5e	Propyl	H	Me	Cl	241-242	60	75	12	82
5f	CF3	H	H	H	222-223	60	71	14	85
5g	CF3	H	H	Me	238-239	60	66	15	81
5h	CF3	Cl	H	Cl	212-213	60	69	12	82
5i	CF3	H	H	Cl	208-209	60	71	16	84