Development and Validation of RP-HPLC Method for Simultaneous Estimation of Aspirin and Esomeprazole Magnesium in Tablet Dosage Form

Table 1

Summary of validation parameters.

Parameters	ASP	ESO
Recovery %	99.80–100.57	99.70–100.83
Repeatability (C.V., 𝑛=6)	0.205123	0.537209
Precision (% RSD)
Intra-day (𝑛=3)	0.14–0.38	0.22–0.49
Inter-day (𝑛=3)	0.38–0.83	0.22–0.86
Limit of detection (𝜇g/mL)	3.25067	2.09632
Limit of quantitation (𝜇g/mL)	9.85051	6.35250
Specificity	Specific	Specific
Robustness	Robust	Robust
Solvent stability	Solvent stable for 24 hrs.	Solvent stable for 24 hrs.