Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives

Table 1

Physical and analytical data of 6-substituted-pyrimidine derivatives (4a, b and 5a–f).

Compd.	R	M.P. (°C)^a	Yield (%)	Molecular formula	Elemental Analysis (%) Calcd/Found.
					C	H	N
4a		154	89	C16H16N4	72.72	6.06	21.21
					72.79	6.01	21.24
4b		111	88	C17H18N4	73.38	6.47	20.14
					73.41	6.51	20.11
5a		178	79	C16H16N4O	68.57	5.71	20.00
					68.59	5.72	19.98
5b		130	28	C17H19N5	69.62	6.48	23.89
					69.58	6.58	23.88
5c		118	87	C18H21N5	70.35	6.84	22.80
					70.39	5.78	22.75
5d		174	71	C19H21N5O2	64.95	5.98	19.94
					65.04	6.02	20.01
5e		164	67	C22H21N5	74.36	5.91	19.71
					74.28	6.09	19.88
5f		185	64	C20H19N7	67.22	5.32	27.45
					67.39	5.14	27.61

aRecrystallization from CHCl₃/THF.