Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives

Table 6

Physical and analytical data of 6-[(4,5,6-trisubstituted-2-phenyl-pyridin-3-yl)thio]-5-cyano-4-methyl-2-phenyl-pyrimidine derivatives (16a–f).

Compd.	R	R′	R′′	M.P. (°C)^a	Yield (%)	Molecular; formula	Elemental analysis (%); Calcd/Found.
							C	H	N
16a		H	H	218	55	C29H20N4S	76.31	4.38	12.28
							76.44	4.49	12.24
16b		H	H	203	41	C27H18N4S2	70.12	3.89	12.12
							70.31	3.94	12.16
16c		H	H	217	50	C28H19N5S	73.52	4.15	15.31
							73.59	4.29	15.55
16d		CN	H	200	47	C30H19N5S	74.84	3.95	14.55
							74.65	4.02	14.68
16e		H	CH3	205	48	C28H20N4S2	70.58	4.20	11.76
							70.66	4.48	11.84
16f	CH3		H	230	46	C31H22N4OS	74.69	4.41	11.24
							74.88	4.52	11.36

aRecrystallization from CH₃COOH/DMF.