Rapid and Economic Access to Some NSAIDS-Based Bioactive Heterocycles

Table 6

Analgesic activity of compounds 6a–6j.

Compound	Dose (mg/kg)	Number of writhes in 10 min after; treatment (mean ± SEM)	% Inhibition
Control	—	32.8333±1.249444	0.00
Ibuprofen	20	13.000±0.5163978^∗∗∗	60.045
6a	55	18.16667±1.137737^∗∗∗	44.50667
6b	55	16.3333±0.9189366^∗∗∗	49.950
6c	75	18.83333±0.7923243^∗∗∗	42.318
6d	75	20.16667±0.4772607^∗∗∗	38.25333
6e	175.0	8.3333±0.421637^∗∗∗	74.49333
Control	—	35.200±1.157584	0.00
Aceclofenac	20	7.166667±0.6009252^∗∗∗	79.58833
6f	55	24.66667±0.4944133^∗∗∗	29.215
6g	75	19.66667±0.6666^∗∗∗	44.02833
6h	55	11.16667±0.6009252^∗∗∗	66.92667
6i	175.0	23.66667±0.9189366^∗∗∗	32.68833
6j	175.0	11.16667±0.6009252^∗∗∗	68.055

Data analyzed by one-way ANOVA followed by Dunnett's Multiple-Comparison Test (𝑛=6), ***𝑃<0.05 significant from control.