Journal of Chemistry / 2013 / Article / Tab 4

Research Article

Synthesis of Polyfunctionalized 4H-Pyrans

Table 4

Synthesis of substituted pyrans from ethyl acetoacetate via Scheme 1.a,b

785930.tab.004

EntryRProductTime (h)% Yieldcm.p. (°C)

13-NO2C6H42a2.591182– 184 [12]
24-NO2C6H42b2.588180- 181 [12]
34-ClC6H42c3.083173- 174 [12]
4Ph2d3.075194– 196 [12]
54-MeOC6H42e4.077135- 136 [12]
63,4,5-(OMe)3C6H22f5.081165-166
73-OHC6H42g3.586161- 162 [12]
8n-C6H132h682163–165

aAll reactions were carried out at room temperature; bequimolar ratio of all the reactants with 30 mg Amberlyst A21/mmol of aldehyde; cisolated yields.

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