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Journal of Chemistry
Volume 2013 (2013), Article ID 789743, 8 pages
Research Article

Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical , -Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes

1Department of Chemistry, Government College University, Faisalabad 38000, Pakistan
2Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan
3Institute of Advanced Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
4Department of Chemistry, Faculty of Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

Received 4 July 2013; Revised 9 September 2013; Accepted 9 September 2013

Academic Editor: Liviu Mitu

Copyright © 2013 Muhammad Jamil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of some novel , -bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4 {CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3 (L2), 2,4-(Cl)2C6H3 (L3), 2,5-(Cl)2C6H3 (L4), and 2-NH2C6H4 (L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. These compounds (L1–L5) and their metal(II) complexes (C1–C10) have been characterized by elemental analysis, infrared spectroscopy, 1H NMR and 13C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML]2. These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities.