Tyrosinase Inhibitory Activity, 3D QSAR, and Molecular Docking Study of 2,5-Disubstituted-1,3,4-Oxadiazoles

Table 2

Tyrosinase inhibition activity of title compounds.

Compound	Percentage inhibition of enzyme tyrosinase
	10 μg	20 μg	40 μg	80 μg	100 μg
Kojic acid	7.86	15.22	28.95	42.52	54.01
4a	2.71	4.02	5.38	7.21	15.21
4b	2.61	3.62	7.51	10.12	8.91
4c	4.38	17.89	25.39	35.41	40.51
4d	4.91	15.67	23.77	32.18	36.13
4e	5.03	12.38	20.61	28.41	38.11
4f	2.71	5.54	7.81	10.02	12.02
4g	2.57	6.91	8.27	12.14	17.61
4h	6.57	18.37	28.16	34.59	39.71
4i	4.71	10.62	18.71	28.72	35.78
4j	3.68	15.12	21.91	27.83	33.81
4k	2.27	6.92	10.61	12.18	18.62
4l	3.11	12.62	20.68	25.51	32.56
4m	3.98	15.68	28.19	37.76	41.14
4n	2.51	10.16	12.72	16.22	22.16
4o	2.97	8.91	15.74	22.02	28.34
4p	4.18	15.71	17.81	22.61	31.57
4q	3.38	8.62	20.63	26.51	34.62
4r	4.61	15.76	28.63	36.44	47.92
4s	4.01	11.88	20.81	26.61	31.54
4t	4.62	10.81	15.42	20.98	33.02