Tyrosinase Inhibitory Activity, 3D QSAR, and Molecular Docking Study of 2,5-Disubstituted-1,3,4-Oxadiazoles

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td align="left">Model number</td><td align="center">Equation</td><td align="center"><span style="width: 7.8874998px;"><svg height="7.1374998" id="M11" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
</text>
</g>
</g>
</svg></span></td><td align="center"><span style="width: 12.6px;"><svg height="13.775" id="M12" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 12.6 13.775" width="12.6" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.775)">
<g transform="translate(72,-60.98)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑟</tspan>
</text>
<text transform="matrix(1,0,0,-1,-66.85,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">2</tspan>
</text>
</g>
</g>
</svg></span></td><td align="center"><span style="width: 14px;"><svg height="16.637501" id="M13" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 14 16.637501" width="14" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.6375)">
<g transform="translate(72,-58.69)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑞</tspan>
</text>
<text transform="matrix(1,0,0,-1,-65.72,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">2</tspan>
</text>
</g>
</g>
</svg></span></td><td align="center"><svg height="10.325" id="M14" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 12.05 10.325" width="12.05" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝐹</tspan>
</text>
</g>
</g>
</svg> test</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td align="left">1.</td><td align="center">Log % <svg height="16.625" id="M15" style="vertical-align:-5.04861pt" version="1.1" viewbox="0 0 36.787498 16.625" width="36.787498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,16.625)">
<g transform="translate(72,-58.7)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝐼</tspan>
</text>
<text transform="matrix(1,0,0,-1,-65.95,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">1</tspan>
<tspan style="font-size: 8.75px; " x="4.3759999" y="0">0</tspan>
<tspan style="font-size: 8.75px; " x="8.7519999" y="0">0</tspan>
<tspan style="font-size: 8.75px; " x="13.128" y="0">𝜇</tspan>
</text>
<text transform="matrix(1,0,0,-1,-47.49,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">g</tspan>
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</svg> = −0.0005 − 147.0670 (±10.4994)<br/>S_793 + 0.0183 (±0.0028) S_757 + 0.0339 (±0.0074) E_550</td><td align="center">16</td><td align="center">0.8920</td><td align="center">0.8187</td><td align="center">33.0329</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Journal of Chemistry

tab3

Table 3

Table 3: Tyrosinase Inhibitory Activity, 3D QSAR, and Molecular Docking Study of 2,5-Disubstituted-1,3,4-Oxadiazoles 