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Journal of Chemistry
Volume 2013, Article ID 851297, 13 pages
Review Article

2-Chloroquinoline-3-carbaldehyde II: Synthesis, Reactions, and Applications

1Applied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt
2Shaqra University, Dawadami, Saudi Arabia
3Chemical Industries Division, National Research Centre, Dokki, Giza 12622, Egypt
4Chemistry Department, Faculty of Science, Jazan University, Saudi Arabia

Received 13 May 2013; Accepted 17 September 2013

Academic Editor: Patricia Valentao

Copyright © 2013 Bakr F. Abdel-Wahab and Rizk E. Khidre. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This review deals with synthesis and reactions of 2-chloroquinoline-3-carbaldehyde during the period from 1979 to 1999. The reactions are subdivided in groups that cover the reactions of chloro- and aldehyde substituent as well as reactions which involve both groups. Some of these reactions have been applied successfully to synthesis of biologically important compounds. The main purpose of this review is to present a survey of the literature on 2-chloroquinoline-3-carbaldehyde chemistry and provide useful and up-to-date data for organic and medicinal chemist since such compound has not been previously reviewed in this period.