Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems of p-Amino Salicylic Acid as Antimycobacterial Agents

Table 1

Antimycobacterial activity versus M. fortuitum ATCC 6841 and primary antituberculosis activity screening results.

Compd. no.	MIC/μg mL^a	MIC/μg mL^b	Inhibition^c (%)
2 b	64	>12.5	85
3b	64	>12.5	87
4	>128	<12.5	95
6	64	>12.5	85
7	64	>12.5	88
8a	64	<12.5	90
9b	>128	<12.5	92
13	>128	<12.5	96
14	>128	>12.5	90
15	>128	>12.5	90

^aMIC affecting M. fortuitum ATCC6841.
^bMIC affecting M. tuberculosis H₃₇Rv.
^cReduction of mycobacterial growth using M. tuberculosis H₃₇Rv using 12.5 μg/mL concentration of compounds.