Synthesis and Biological Evaluation of Novel 5,7-Dichloro-1,3-benzoxazole Derivatives

Table 6

Pancreatic lipase inhibitory activity of compounds 4–11.

Compounds	Inhibition of lipase activity (%)
	20 mg/mL	10 mg/mL	5 mg/mL	2.5 mg/mL	0 mg/mL
4	35.19	20.07	10.00	06.55	0.0
5	39.84	30.54	20.46	09.44	0.0
6	37.90	22.79	21.55	10.95	0.0
7	50.69	35.96	23.30	12.01	0.0
8	57.28	42.94	29.05	14.34	0.0
9	59.80	38.68	27.82	15.42	0.0
10	59.80	41.39	25.50	16.45	0.0
11	72.86	54.94	40.67	19.77	0.0
Standard	96.61	94.30	93.12	89.21	0.0

Standard-Orlistat.