Journal of Chemistry
Volume 2013, Article ID 865128, 4 pages
http://dx.doi.org/10.1155/2013/865128
Antimicrobial Activity of Some Derivatives of 1,4-Dihydropyridines
Department of Chemistry, Government Autonomous K.R.G. College, Gwalior 474002, India
Received 7 December 2011; Accepted 30 August 2012
Academic Editor: Franck Le Derf
Copyright © 2013 Prabha Mehta and Prabha Verma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Hantzsch reported the synthesis of functionalized 1,4-dihydropyridines via three-component condensation of an aromatic aldehyde, ketoester, and ammonium hydroxide. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyridines. In this account, we synthesized some halo- and nitrophenyl dihydropyridines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by microdilution technique in Mueller Hinton broth. The MICs were recorded after 24 hours of incubation at 37°C. These results showed that these compounds exhibited significant to moderate activities against both Gram-(+) and Gram-(−) organisms.