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Journal of Chemistry
Volume 2013, Article ID 872056, 6 pages
Research Article

HMG-CoA Reductase Inhibitors from Monascus-Fermented Rice

Beijing Peking University WBL Biotechnology Co., Ltd., Beijing 100094, China

Received 3 August 2013; Revised 11 October 2013; Accepted 22 October 2013

Academic Editor: Marjana Novic

Copyright © 2013 Xuemei Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Seven compounds were isolated from Monascus-fermented rice by column chromatography with silica gel and semiprep HPLC. Their structures were elucidated by extensive spectroscopic methods. All compounds displayed HMG-CoA reductase inhibitory potential, among them compound 7 exhibited strong inhibition with IC50 value comparable with lovastatin. In this study, two compounds (1 and 2) were obtained from natural source for the first time.