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Journal of Chemistry
Volume 2013, Article ID 915381, 7 pages
Research Article

Synthesis and Bioevaluation of Novel Imatinib Base Derivatives via 1,1′-Carbonyldiimidazole Catalyst

1Department of Chemistry, J.J.T. University, Rajasthan, India
2Department of Chemistry, Navjivan Science College, Gujarat University, Dahod, Gujarat 389151, India

Received 27 June 2013; Revised 19 September 2013; Accepted 21 September 2013

Academic Editor: Olga Gortzi

Copyright © 2013 M. J. Patoliya and G. J. Kharadi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of eleven compounds were synthesized from 6-methyl-N′-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine with various substituted carboxylic acid under solvent-free conditions using 1,1′-carbonyldiimidazole (CDI) as a catalyst. The yields of compounds are more than 72%. All the compounds were characterized by physical, spectroscopic, and elemental analysis. Compound 8b exhibited good inhibition towards antimicrobial activity compared to the other compounds.