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Journal of Chemistry
Volume 2013, Article ID 930354, 8 pages
http://dx.doi.org/10.1155/2013/930354
Research Article

Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist

1Department of Pharmaceutical Chemistry, MVP’s College of Pharmacy, Gangapur Road, Nashik, Maharashtra 422002, India
2Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Kusgaon Budruk, Lonavala, Maharashtra 410401, India

Received 3 May 2013; Accepted 30 July 2013

Academic Editor: John Gebler

Copyright © 2013 Mahantesh Namdev Jadhav et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Schizophrenia is a mental disorder manifested largely by disintegration of thought processes and emotional responsiveness. Given the therapeutic and toxic limitations of clinically available drugs, it is clear that there is still a need for the development of new generation antipsychotic agents with an improved clinical profile. Development of novel hybrid atypical tricyclic antipsychotic pharmacophore was achieved using direct (by measuring docking score of designed molecules on modelled 5- receptor) and indirect (current, clinically available therapeutic agents’ data) drug design approaches.