Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT_2A Antagonist

Table 1

The distance between N4 and C-2/C-8 of tricyclic ring.

Sr. no.	Molecule	Distance between N4 and C-2 of tricyclic ring (Å)	Distance between N4 and C-8 of tricyclic ring (Å)
(1)	Clozapine	6.256	8.660
(2)	Loxapine	6.301	8.717
(3)	Quetiapine	6.891	7.848
(4)	Olanzapine	6.354	8.667
(5)	Designed benzyl derivatives	6.659	7.544
(6)	Designed benzoyl derivatives	6.446	8.650