Synthesis of (±)-Pisonivanone and Other Analogs as Potent Antituberculosis Agents

Table 2

Anti oxidant and cytotoxic activity of chalcones (Compounds 3a–h).

Superoxide Inhibitory Activity				DPPH Inhibitory Activity			Brine Shrimp Lethality Test
	Dose at (𝜇g/mL)	% of inhibition	IC50	Dose at (𝜇g/mL)	% of Inhibition	IC50	ED50
Compound-3a	50	4.58	93.89	50	8.36	85.74	46.56
	75	28.92		75	32.12
	100	57.03		100	69.94
Compound-3b	50	7.35	90.95	50	20.73	78.49	56.45
	75	25.33		75	47.27
	100	63.56		100	71.52
Compound-3c	50	18.63	86.58	50	23.15	75.42	63.29
	75	36.76		75	50.06
	100	69.44		100	75.52
Compound-3d	50	25.82	85.52	50	20.61	77.29	32.45
	100	45.42		75	47.64
	150	79.25		100	74.42
Compound-3e	25	30.88	83.27	50	28.97	74.90	28.34
	50	47.06		75	49.94
	75	78.43		100	71.52
Compound-3f	50	31.05	80.15	50	20.48	91.14	35.26
	75	61.76		75	36.97
	100	76.63		100	57.09
Compound-3g	50	12.75	86.58	50	23.15	75.42	38.56
	75	33.01		75	50.06
	100	66.83		100	75.52
Compound-3h	25	6.05	85.52	50	20.61	77.29	25.36
	50	37.09		75	47.64
	75	56.37		100	74.42
Vit-C	2.5	34.49	3.98	2.5	34.49	3.98	Phodophyllotoxin 3.69
	5	62.71		5	62.71
	10	102.27		10	102.27