Synthesis of (±)-Pisonivanone and Other Analogs as Potent Antituberculosis Agents

Table 3

Anti oxidant and cytotoxic activity of Flavanones (Compounds 4a–h).

Superoxide Inhibitory Activity				DPPH Inhibitory Activity			Brine Shrimp Lethality Test
Test name	Dose at (𝜇g/mL)	% of Inhibition	IC50	Dose at (𝜇g/mL)	% of Inhibition	IC50	ED50
Compound-4a	10	13.89	44.99	10	11.27	48.77	34.11
	25	37.58		25	35.76
	50	54.41		50	58.18
Compound-4b	10	26.58	29.18	10	14.06	36.35	22.55
	25	48.67		25	40.73
	50	72.00		50	65.21
Compound-4c	10	24.02	33.00	10	25.61	29.24	31.22
	25	43.30		25	42.68
	50	67.65		50	78.15
Compound-4d	10	20.75	32.68	10	26.20	25.81	27.33
	25	47.55		25	57.34
	50	67.16		50	77.29
Compound-4e	10	28.27	28.77	10	9.70	42.39	41.82
	25	49.02		25	37.94
	50	71.41		50	55.76
Compound-4f	10	10.23	39.03	10	18.30	38.08	52.15
	25	32.81		25	39.27
	50	64.06		50	61.45
Compound-4g	10	17.65	36.24	10	17.82	32.28	28.93
	25	42.16		25	46.79
	50	63.73		50	70.30
Compound-4h	10	17.34	31.95	10	16.48	33.28	42.56
	25	41.35		25	43.64
	50	75.64		50	70.30
Compound-5	5	12.42	25.32	10	31.53	20.14	14.35
	10	46.41		25	64.50
	25	66.18		50	86.76
Vit-C	2.5	34.49	3.98	2.5	34.49	3.98	Phodophyllotoxin 3.69
	5	62.71		5	62.71
	10	102.27		10	102.27