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Journal of Chemistry
Volume 2014, Article ID 173814, 7 pages
Research Article

Synthesis, Characterization and In Vitro Anticancer Evaluation of Itaconic Acid Based Random Copolyester

PG & Research Department of Chemistry, Pachaiyappa’s College, Chennai 600 030, India

Received 23 May 2013; Revised 4 October 2013; Accepted 22 October 2013; Published 16 January 2014

Academic Editor: Xinyong Liu

Copyright © 2014 J. Gowsika and R. Nanthini. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study deals with the synthesis and characterization of an aliphatic copolyester, poly [butylene fumarate-co-butylene itaconate] (PIFB) copolymer was obtained from itaconic acid, fumaric acid, and 1,4-butanediol using titanium tetraisopropoxide (TTiPO) through a two step process of transesterification and melt polycondensation. The synthesized aliphatic random copolyester was characterized with the help of FT-IR, 1H-NMR, 13C-NMR, viscosity measurements, Gel Permeation Chromatography (GPC) and X-ray diffraction (XRD) analysis. Thermal properties have been analyzed using thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC). Hydrolytic degradation studies were carried out in acid and alkaline regions of various pH values. The synthesized copolymer was subjected to in vitro anticancer activity studies against human breast cancer (MCF-7) cell line.