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Journal of Chemistry
Volume 2014, Article ID 217596, 15 pages
Review Article

Fused Imidazopyrazoles: Synthetic Strategies and Medicinal Applications

1Chemical Industries Division, National Research Centre, Dokki, Giza 12622, Egypt
2Chemistry Department, Faculty of Science, Jazan University, Saudi Arabia
3Applied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt
4Chemistry Department, Faculty of Science, Shaqra University, Al Dawadmi, Saudi Arabia
5Chemical Engineering Department, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia

Received 7 June 2014; Accepted 18 July 2014; Published 14 August 2014

Academic Editor: Liviu Mitu

Copyright © 2014 Rizk E. Khidre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The current review summarizes the known synthetic routes of fused imidazopyrazoles. This review is classified into two main categories based on the type of annulations, for example, annulation of the imidazole ring onto a pyrazole scaffold or annulation of the pyrazole ring onto an imidazole scaffold. Some medicinal applications of imidazopyrazoles are mentioned.