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Journal of Chemistry
Volume 2014, Article ID 293972, 8 pages
http://dx.doi.org/10.1155/2014/293972
Research Article

Salt Effect on the Cloud Point Phenomenon of Amphiphilic Drug-Hydroxypropylmethyl Cellulose System

1Surfactant Research Chair, Department of Chemistry, College of Science, King Saud University, Riyadh 11541, Saudi Arabia
2Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India

Received 12 January 2014; Revised 20 March 2014; Accepted 20 March 2014; Published 13 April 2014

Academic Editor: Jean-Luc Blin

Copyright © 2014 Mohd. Sajid Ali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Effect of two amphiphilic drugs (tricyclic antidepressant, nortriptyline hydrochloride (NORT), and nonsteroidal anti-inflammatory drug, sodium salt of ibuprofen (IBF)) on the cloud point of biopolymer hydroxypropylmethyl cellulose (HPMC) was studied. Effect of NaCl was also seen on the CP of HPMC-drug system. CP of HPMC increases uniformly on increasing the (drug). Both drugs, though one being anionic (IBF) and other cationic (NORT), affect the CP in almost the same manner but with different extent implying the role of hydrophobicity in the interaction between drug and polymer. Salt affects the CP of the drug in a dramatic way as low concentration of salt was only able to increase the value of the CP, though not affecting the pattern. However, in presence of high concentration of salts, minimum was observed on CP versus (drug) plots. Various thermodynamic parameters were evaluated and discussed on the basis of the observed results.