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Journal of Chemistry
Volume 2014 (2014), Article ID 294246, 5 pages
http://dx.doi.org/10.1155/2014/294246
Research Article

Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor

Laboratorio de Diseño Molecular, Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, 58033 Morelia, MICH, Mexico

Received 13 March 2014; Accepted 17 April 2014; Published 9 July 2014

Academic Editor: Hugo Verli

Copyright © 2014 Salvador Gallardo-Alfonzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The synthesis of the novel 1-adamantyl-(N-meso-dipyrrolylmethylene)-carboxamide is described, providing a three-step, two-pot reaction. Docking studies with 11β-HSD1 revealed favorable binding interactions with the enzyme.