Synthesis and Docking Studies of the Novel N-(2,2-Di(1H-pyrrol-2-yl)ethyl)adamantane-1-carboxamide, a Potential 11β-HSD1 Inhibitor

Table 1

Binding energy and kI for compounds 1 and NN1 toward the 11𝛽-HSD1 active site calculated from the docking studies.

Compound	Binding energy (Δ𝐺)	kI (nM)
1	−9.68	80.64
NN1	−10.4	23.97