Research Article
Pharmacokinetic Comparison of Isoalantolactone and Alantolactone in Rats after Administration Separately by Optimization of an UPLC-MS2 Method
Table 2
Extraction recovery and matrix effect of the method (
).
| Nominal concentration | Extraction recovery | Mean matrix effect | (ng/mL) | (%) | (%) |
| Isoalantolactone | | | 5 | 93.59 ± 5.56 | 109.11 ± 6.69 | 50 | 89.33 ± 4.06 | 108.32 ± 3.76 | 400 | 84.02 ± 2.05 | 103.54 ± 3.98 | Alantolactone | | | 5 | 91.91 ± 6.01 | 109.44 ± 2.00 | 50 | 88.64 ± 4.53 | 107.91 ± 3.85 | 400 | 83.61 ± 2.52 | 100.84 ± 2.88 | IS | | | 0.1 | 94.09 ± 8.61 | 101.76 ± 5.96 |
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