Pharmacokinetic Comparison of Isoalantolactone and Alantolactone in Rats after Administration Separately by Optimization of an UPLC-MS² Method

Table 2

Extraction recovery and matrix effect of the method ().

Nominal concentration	Extraction recovery	Mean matrix effect
(ng/mL)	(%)	(%)
Isoalantolactone
5	93.59 ± 5.56	109.11 ± 6.69
50	89.33 ± 4.06	108.32 ± 3.76
400	84.02 ± 2.05	103.54 ± 3.98
Alantolactone
5	91.91 ± 6.01	109.44 ± 2.00
50	88.64 ± 4.53	107.91 ± 3.85
400	83.61 ± 2.52	100.84 ± 2.88
IS
0.1	94.09 ± 8.61	101.76 ± 5.96