Pharmacokinetic Comparison of Isoalantolactone and Alantolactone in Rats after Administration Separately by Optimization of an UPLC-MS² Method

Table 4

Mean plasma concentrations of the lactones (, ng/mL) over time.

(h)	i.v. administration (5 mg/kg)
	Isoalantolactone	Alantolactone
0.083	356.69 ± 79.93^a	336.23 ± 75.56
0.25	80.31 ± 44.97	121.87 ± 40.28
0.5	29.04 ± 9.71	66.01 ± 10.94
0.75	16.97 ± 7.63	54.52 ± 5.64
1	8.10 ± 2.06	44.10 ± 8.65
2	7.44 ± 1.05	22.87 ± 7.04
4	5.63 ± 1.80	14.03 ± 2.59
6	4.05 ± 0.72	8.05 ± 1.37
10	3.57 ± 0.75	5.92 ± 1.16

Mean ± SD.