Pharmacokinetic Comparison of Isoalantolactone and Alantolactone in Rats after Administration Separately by Optimization of an UPLC-MS² Method

Table 5

Pharmacokinetic parameters of the lactones in rats^a,b.

Parameter	i.v. administration (5 mg/kg)
	Isoalantolactone	Alantolactone
Kel (h)	0.17 ± 0.08^**	0.60 ± 0.32
MRT (h)	4.86 ± 2.86	4.80 ± 2.51
CL (L/h/kg)	30.61 ± 6.16^**	18.59 ± 1.54
(ng/mL)	0.13 ± 0.05^*	0.17 ± 0.07
AUC (h ng/mL)	170.19 ± 41.12^**	270.49 ± 22.10
AUMC (h ng/mL)	903.99 ± 803.19	1303.44 ± 688.08
Vss (L)	138.44 ± 54.14	88.99 ± 46.07
	775.41 ± 233.50	389.92 ± 206.83
	764.81 ± 231.31	359.33 ± 195.86
Alpha	10.60 ± 3.73	30.59 ± 13.43
Beta	9.77 ± 3.75	4.11 ± 2.31

Mean ± SD.
^bStatistical significance indicated by and versus the alantolactone group.