Synthesis and Antimicrobial Activity of Bis-4,6-sulfonamidated 5,7-Dinitrobenzofuroxans

Table 1

The in vitro antimicrobial activity of the synthesized compounds and the control drugs (1 mg/mL).

Compound number	Microorganisms, zone of inhibition (diameter, in mm)
	Staphylococcus aureus	Escherichia сoli	Pseudomonas aeruginosa	Proteus mirabilis	Aspergillus niger	Candida albicans
1	17	—	—	—	10	15
Sulfanilamide (2)	20	17	15	12	7	9
7	21	20	7	11	15	27
8	24	25	26	15	17	21
9	18	13	18	13	15	20
10	25	21	25	17	18	23
11	21	21	10	12	13	30
Penicillin G	21	20	8	10	—	—
Rifampicin	25	21	—	—	—	—
Ketoconazole	—	—	—	—	11	18
Nystatin	—	—	—	—	18	21
DMSO	—	—	—	—	—	—

Shown are mean values of triplicate tests; “—” indicates no significant inhibitory effect (<6 mm).