Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors

Table 2

CDK2 inhibiting activity of fluorinated 1,2,4-triazinones 1–18.

Compounds	IC50  ± SD (μM)^a
1	3.8 ± 1.7
3	5.0 ± 1.7
5	12.8 ± 1.7
6	12.2 ± 1.7
9	14.0 ± 1.5
10	15.0 ± 2.5
11	15.0 ± 5.0
14	4.5 ± 2.8
15	4.1 ± 2.8
16	4.0 ± 2.8
17	16.2 ± 5.0
18	18.1 ± 4.0
Olomoucine	5.0 ± 1.0

aIC₅₀ in μM/𝑑_𝑚⁻¹.
SD: standard deviation.