Design and Synthesis of an Indole-Estrogen Derivative

Figure 5

Synthesis of 3-[4-(2-butyl-3-cyclohexylimino-4-piperidin-1-yl-cyclobutylidencarbamoyl)]-phenoxy-NH-indolo[2′,3′:17,16]estra-1,3,5(10)triene (10). Reaction of 7 with 1-hexyne (8) and ,-Dicyclohexylcarbodiimide (9) to form 10. (vii) = cupric chloride/rt.