In Silico Study of Leishmania donovani α-β Tubulin and Inhibitors

Table 3

Antiparasitic activities of oxadiazole analogues against L. donovani in vitro and energy values (kcas mol⁻¹) for docked pose.

Compd	pIC50	Colchicine domain 𝐸Score	Vinca domain 𝐸Score	N loop domain 𝐸Score
12	57.0	−90.25	−93.3	−6.89
13	19.0	−92.16	−88.78	−67.65
14	34.0	−97.78	−85.36	−67.92
15	58.0	−99.19	−95.91	−71.69
16	43.0	−111.43	−90.73	−97.71
17	54.0	−110.16	−98	−56.70
18	89.0	−108.24	−96.87	−70.45
19	108.0	−115.61	−99.48	−49.73