Journal of Chemistry / 2014 / Article / Sch 1

Research Article

Synthesis and Biological Evaluation of New Substituted 3-[4-(Phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one Derivatives as α-Glucosidase Inhibitors

Scheme 1

Synthesis of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives 1026. Reagents and conditions: (a) SOCl2, 1,2,3-benzotriazole, and reflux; (b) ethyl acetoacetate, NaH, THF, and rt; (c) SnCl2, ethyl acetate, and reflux; (d) substituted benzenesulfonyl chloride, pyridine, CH2Cl2, −10°C, and then rt; (e) substituted salicylaldehyde, piperidine, acetic acid, EtOH, and reflux.