Journal of Chemistry / 2014 / Article / Tab 1

Research Article

Synthesis and Biological Evaluation of New Substituted 3-[4-(Phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one Derivatives as α-Glucosidase Inhibitors

Table 1

The α-glucosidase inhibitory activity of new substituted 3- 4-(phenylsulfonamido)benzoyl -2H-1-benzopyran-2-one derivatives.

Number IC50 ( M)a

10HHF7.568 ± 0.575
11HOHF0.282 ± 0.038
12HN(C2H5)2F0.085 ± 0.014
13OCH3OHF0.075 ± 0.012
14HHCl1.088 ± 0.232
15HOHCl0.171 ± 0.034
16HN(C2H5)2Cl0.108 ± 0.019
17OCH3OHCl0.025 ± 0.005
18HHBr0.014 ± 0.003
19HOHBr0.199 ± 0.016
20HN(C2H5)2Br0.125 ± 0.035
21OCH3OHBr0.036 ± 0.008
22HHOCH30.073 ± 0.012
23HOHOCH30.018 ± 0.003
24HN(C2H5)2OCH30.037 ± 0.006
25OCH3OHOCH30.069 ± 0.011
26HN(C2H5)2C(CH3)3b
Acarbose            29.26 ± 3.23

IC50 values are represented as means ± SD ( = 2-3). bLess than 50% inhibition at 10  g/mL.