Synthesis and In Vitro and In Vivo Evaluation of a New ⁶⁸Ga-Semicarbazone Complex: Potential PET Radiopharmaceutical for Tumor Imaging

Table 1

Biodistribution of ⁶⁸Ga-(2-acetylpyridine semicarbazone)₂ complex (⁶⁸Ga-[APSC]₂) in tumor bearing nude mice.

	1 h	2 h	4 h	24 h*
Blood	17.71 ± 1.33	6.41 ± 0.10	3.45 ± 0.57	2.13 ± 0.08
Liver	7.04 ± 0.06	4.14 ± 0.31	3.51 ± 0.09	2.13 ± 0.53
Lung	7.34 ± 0.37	4.03 ± 0.27	3.61 ± 0.72	1.87 ± 0.20
Kidney	6.18 ± 0.94	4.81 ± 0.47	3.25 ± 0.21	6.15 ± 0.72
Intestine	5.21 ± 0.44	8.22 ± 0.02	3.80 ± 0.89	3.76 ± 0.68
Heart	5.75 ± 0.92	2.31 ± 0.55	2.16 ± 0.27	1.07 ± 0.08
Muscle	2.33 ± 0.33	1.54 ± 0.49	0.75 ± 0.11	0.37 ± 0.08
Spleen	4.76 ± 0.43	5.01 ± 0.80	3.88 ± 0.24	2.88 ± 0.26
Tumor	3.52 ± 0.59	11.58 ± 1.07	4.08 ± 0.04	2.22 ± 0.01

The values are average of % injected dose/gram ± SD for .
Animals were injected with ⁶⁷Ga-[APSC]₂ radiotracer.