A Validated HPLC-DAD Method for Simultaneous Determination of Etodolac and Pantoprazole in Rat Plasma

Table 2

Data of back-calculated PTZ and ETD concentrations of the calibration standards in rat plasma.

Drug	Nominal concentration (gmL^−1)	Mean^a  ± SD (gmL^−1)	Precision (% RSD)	Accuracy (% error)
PTZ	0.1	0.11 ± 0.01	9.09	10
	0.5	0.50 ± 0.01	2.78	0.67
	1.0	1.09 ± 0.07	6.88	8.68
	3.0	3.14 ± 0.22	7.01	4.67
	5.0	4.93 ± 0.39	7.91	−1.43
	7.0	7.44 ± 0.38	5.11	6.31
	10.0	9.77 ± 0.79	8.08	−2.23
	15.0	14.39 ± 0.68	4.72	−4.07
ETD	5.0	4.97 ± 0.24	4.83	−0.57
	10.0	10.64 ± 0.80	7.52	6.40
	15.0	14.90 ± 0.52	3.49	−0.67
	25.0	24.13 ± 1.21	5.01	−3.48
	30.0	32.51 ± 1.99	6.12	8.37
	35.0	36.93 ± 1.39	3.76	5.51
	45.0	42.25 ± 2.88	6.82	−6.11
	50.0	52.03 ± 1.91	3.67	4.06

Average of six replicates.