A Validated HPLC-DAD Method for Simultaneous Determination of Etodolac and Pantoprazole in Rat Plasma

Table 3

Intraday and interday accuracy and precision of quality control samples of PTZ and ETD obtained by HPLC-DAD.

Day of analysis	PTZ			ETD
	Low QC	Medium QC	High QC	Low QC	Medium QC	High QC
	(0.3 gmL^−1)	(6 gmL^−1)	(12 gmL^−1)	(8 gmL^−1)	(20 gmL^−1)	(40 gmL^−1)
Day 1	0.296	5.94	13.27	8.36	21.24	42.63
	0.286	5.67	12.47	8.15	20.37	41.65
	0.312	6.23	12.84	8.91	20.56	42.19
	0.326	6.84	12.08	7.62	19.62	39.41
	0.249	6.45	11.99	7.98	19.10	43.54
Day 2	0.281	5.86	12.61	9.11	20.28	39.16
	0.274	5.34	11.83	7.64	21.71	39.08
	0.296	6.94	11.26	8.17	19.37	40.42
	0.315	6.41	12.47	8.78	19.88	40.37
	0.292	6.36	13.16	8.94	19.74	41.28
Day 3	0.295	6.14	12.61	9.64	21.13	38.68
	0.308	5.72	11.45	9.82	20.09	39.46
	0.291	6.15	11.27	8.42	20.54	39.44
	0.318	5.73	11.43	8.68	21.81	42.18
	0.315	6.89	12.51	8.28	19.37	41.72
Mean ± SD (gmL^−1)	0.29 ± 0.02	6.18 ± 0.48	12.22 ± 0.66	8.56 ± 0.65	20.32 ± 0.85	40.75 ± 1.52
Precision (% RSD)	6.89	7.76	5.40	7.59	4.18	3.73
Accuracy (% error)	−3.33	2.97	1.83	7.08	1.60	1.87