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Journal of Chemistry
Volume 2014, Article ID 738796, 6 pages
Research Article

Mosquito Larvicidal Constituents from the Ethanol Extract of Inula racemosa Hook. f. Roots against Aedes albopictus

1State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China
2Analytical and Testing Center, Beijing Normal University, Beijing 100875, China
3Department of Entomology, China Agricultural University, 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China

Received 4 March 2014; Revised 6 June 2014; Accepted 9 June 2014; Published 23 June 2014

Academic Editor: Qing Li

Copyright © 2014 Qing He et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this research was to determine larvicidal activity of the ethanol extract of Inula racemosa Hook. f. (Compositae) roots against the larvae of the Culicidae mosquito Aedes albopictus and to isolate any larvicidal constituents from the extract. Based on bioactivity-guided fractionation, 11,13-dihydroisoalantolactone (1), macrophyllilactone E (2), 5α-epoxyalantolactone (3), and epoxyisoalantolactone (4) were isolated and identified as the active constituents. Compounds 1 and 2 exhibited strong larvicidal activity against the early fourth-instar larvae of A. albopictus with LC50 values of 21.86 μg/mL and 18.65 μg/mL, respectively, while the ethanol extract had a LC50 value of 25.23 μg/mL. Compounds 3 and 4 also possessed larvicidal activity against the Asian tiger mosquitoes with LC50 values of 29.37 μg/mL and 35.13 μg/mL, respectively. The results indicated that the ethanol extract of I. racemosa and the four isolated constituents have potential for use in the control of A. albopictus larvae and could be useful in the search of newer, safer, and more effective natural compounds as larvicides.