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Journal of Chemistry
Volume 2014, Article ID 847180, 9 pages
Research Article

Synthesis of Some New Pyrimidine-Azitidinone Analogues and Their Antioxidant, In Vitro Antimicrobial, and Antitubercular Activities

1PG Department of Chemistry, JSS College of Arts, Commerce and Science, Ooty Road, Mysore 570025, India
2Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore 570005, India

Received 15 May 2013; Revised 16 December 2013; Accepted 16 December 2013; Published 10 February 2014

Academic Editor: Sevgi Kolaylı

Copyright © 2014 Mallikarjunaswamy Chandrashekaraiah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of 1-(3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methylphenyl)-3-chloro-4-(2-mercaptoquinolin-3-yl)azetidin-2-one (7a-j) have been synthesized from the condensation of aromatic amines with N-phenylacetamide. The thione nucleus formed from 2-chloroquionoline-3-carbadehyde using sodium sulphide in dimethyl formamide (DMF) was followed by the reaction with pyrimidine amine to form the Schiff base intermediates. Attempt has been made to derive final azetidinone analogues from Schiff bases by using chloroacetyl chloride. The newly synthesized analogues were examined for the antimicrobial activity against some bacterial and fungal strains and in vitro antituberculosis activity against mycobacterium tuberculosis. These observations provide some predictions to design further antibacterial and antituberculosis active compounds prior to their synthesis according to molecular studies.