Synthesis of New [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazines and Study of Their Anti-Candidal and Cytotoxic Activities

Table 2

Anti-Candidal activity of the compounds (5a–h) as MIC values (𝜇g/mL).

	5a	5b	5c	5d	5e	5f	5g	5h	K^#
C. tropicalis ATCC 66029	25	>100	12.5	25	12.5	25	>100	>100	3.0
C. parapsilosis ATCC 22019	12.5	>100	25	12.5	6.25	6.25	25	>100	3.0
C. albicans ATCC 10231	25	>100	25	>100	>100	>100	>100	>100	30.0
C. albicans ATCC 66027	>100	>100	25	12.5	6.25	50	12.5	>100	30.0
Candida sp. [HVS*] 13184	12.5	>100	12.5	>100	>100	>100	>100	>100	7.0
Candida sp. [HVS] 11972	6.25	>100	12.5	>100	>100	>100	>100	>100	7.0
Candida sp. [HVS] 178	>100	>100	50	>100	>100	>100	>100	>100	7.0
Candida sp. [urine] 300	6.25	>100	12.5	>100	6.25	25	6.25	>100	15.0
Candida sp. [urine] 12341	6.25	>100	6.25	>100	25	12.5	25	>100	15.0
Candida sp. [urine] 12485	>100	>100	6.25	50	25	25	25	>100	15.0
Candida sp. [blood] 12810	12.5	>100	25	>100	6.25	>100	25	>100	7.0

∗HVS: high vaginal swab; K^#: ketoconazole.