Chemical Feature-Based Molecular Modeling of Urotensin-II Receptor Antagonists: Generation of Predictive Pharmacophore Model for Early Drug Discovery

Table 6

Interfeature distances (in Å) between the obtained pharmacophore features^a.

	RA1 (IP1)	RA1 (PP1)	RA2 (IP2)	RA2 (PP2)	HBA_L (IP)	HBA_L (PP)
RA1 (IP1)
RA1 (PP1)	3.000
RA2 (IP2)	7.059	8.058
RA2 (PP2)	8.058	9.524	3.000
HBA_L (IP)	6.223	7.032	6.993	9.194
HBA_L (PP)	6.679	8.385	5.635	8.278	3.000
HY	9.683	10.795	3.615	4.774	7.120	5.263

aIP: initial point in the ligand and PP: projected point in the active site of the receptor.