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Journal of Chemistry
Volume 2015 (2015), Article ID 435219, 8 pages
Research Article

Synthesis, Herbicidal Evaluation, and Structure-Activity Relationship of Benzophenone Oxime Ether Derivatives

Department of Chemistry, College of Sciences, Huazhong Agricultural University, Wuhan 430070, China

Received 30 April 2015; Revised 3 July 2015; Accepted 8 July 2015

Academic Editor: Florent Barbault

Copyright © 2015 Jimei Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A novel series of benzophenone oxime ether derivatives with tertiary amine groups were synthesized and their herbicidal activities of 24 compounds against Oryza sativa, Sorghum sudanense, Brassica chinensis, and Amaranthus mangostanus L. were also evaluated. Most of these compounds exhibited significant inhibitory effect on root growth at 20 ppm. Based on the herbicidal activity data, computational Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) analysis and molecular docking were undertaken. CoMFA contour maps were generated for the design of benzophenone oxime ether analogues with enhancing activity.