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Journal of Chemistry
Volume 2015, Article ID 516878, 7 pages
http://dx.doi.org/10.1155/2015/516878
Research Article

In Vitro Enzyme Inhibition Potentials and Antioxidant Activity of Synthetic Flavone Derivatives

1Department of Pharmacy, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, Pakistan
2Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Khyber Pakhtunkhwa 25000, Pakistan
3Department of Chemistry, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, Pakistan
4Department of Physics, University of Sargodha, Punjab 40100, Pakistan
5Department of Statistics, University of Malakand, Chakdara, Dir Lower, Khyber Pakhtunkhwa 18550, Pakistan

Received 8 March 2015; Accepted 23 April 2015

Academic Editor: Dimitris P. Makris

Copyright © 2015 Mohammad Shoaib et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Free radicals are produced by an important chemical process known as oxidation that in turn initiates chain reactions to damage the cells and originate oxidative stress. Flavones have got special position in research field of natural and synthetic organic chemistry due to their biological capabilities as antioxidant. The antioxidants are known to possess extensive biological effects that include antiviral, antibacterial, anti-inflammatory, antithrombotic, and vasodilatory activities. The simple flavone (F1) and substituted flavone derivatives (F2F5) have been synthesized from o-hydroxyacetophenone and benzaldehyde derivatives in good yield. The structures have been established by different spectroscopic techniques like 1H NMR, 13C NMR, IR, and elemental analysis. Antioxidant profile of these compounds was established using DPPH and H2O2 free radical scavenging assay. The findings showed that halogenated flavones showed more enzyme inhibitions and antioxidant activities than simple flavones and are potential candidates for the treatment of wide range of diseases.