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Journal of Chemistry
Volume 2015, Article ID 524056, 8 pages
http://dx.doi.org/10.1155/2015/524056
Research Article

Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation

1Institute of Chemistry, University of Punjab, Lahore 54590, Pakistan
2Institute of Biochemistry & Biotechnology, University of the Punjab, Lahore 54590, Pakistan

Received 21 May 2015; Accepted 2 July 2015

Academic Editor: Deniz Ekinci

Copyright © 2015 Muhammad Abdul Qadir et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

New amidine and benzene sulfonamide derivatives were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, 1HNMR, and 13CNMR). In vitro, developed compounds were screened for their antibacterial and antifungal activities against medically important bacterial strains, namely, S. aureus, B. subtilis, and E. coli, and fungi, namely, A. flavus, A. parasiticus, and A. sp. The antibacterial and antifungal activities have been determined by measuring MIC values (μg/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds 3b, 9a, and 9b have most potent activity against S. aureus, A. flavus, and A. parasiticus, respectively, and were found to be more active than sulfamethoxazole and itraconazole with MIC values 40 μg/mL. In contrast, all the compounds were totally inactive against the A. sp. except 10b and 15b to show activity to some extent.