Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation

Table 2

Zone of inhibition and MIC of sulfonamides against pathogenic bacterial strains.

Compounds	Name of bacteria
	Gram (+) bacterial strains				Gram (−) bacterial strains
	S. aureus		B. subtilis		E. coli
	(ATCC 25923)		(ATCC 6633)		(ATCC 25922)
	Zone of inhibition	MIC	Zone of inhibition	MIC	Zone of inhibition	MIC
3a	—, —, —	—	—, —, —	—	9, —, —	>160
3b	32, 29, 26	40	8, —, —	>160	—, —, —	—
4a	—, —, —	—	—, —, —	—	—, —, —	—
4b	—, —, —	—	—, —, —	—	28, 25, 22	80
6a	—, —, —	—	—, —, —	—	9, —, —	>160
9a	—, —, —	—	9, —, —	160	9, —, —	>160
9b	—, —, —	—	8, —, —	>160	—, —, —	—
10a	9, —, —	>160	—, —, —	—	14, 10, —	160
10b	27, 24, 22	80	—, —, —	—	—, —, —	—
12a	9, —, —	>160	28, 24, 21	80	—, —, —	—
15a	29, 26, 21	80	—, —, —	—	—, —, —	—
15b	—, —, —	—	27, 24, 22	80	28, 25, 20	80
Ciprofloxacin	36, 34, 31	0.5	36, 33, 31	0.5	35, 34, 31	0.5
Sulfamethoxazole	—, —, —	—	16, 13, —	160	33, 28, 25	40

Zone of inhibition was measured in mm at concentration of 160, 80, and 40 μg mL⁻¹.
MIC (minimum inhibitory concentrations) were measured in μg mL⁻¹.
Control drug; sulfa drug.