Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation

Table 3

Zone of inhibition and MIC of sulfonamides against pathogenic fungal strains.

Compounds	Name of fungi
	A. parasiticus		A. flavus		A. sp.
	(ATCC 15517)		(ATCC 9643)		(ATCC 200667)
	Zone of inhibition	MIC	Zone of inhibition	MIC	Zone of inhibition	MIC
3a	—, —, —	—	—, —, —	—	—, —, —	—
3b	—, —, —	—	12, —, —	160	—, —, —	—
4a	9, —, —	>160	—, —, —	—	—, —, —	—
4b	—, —, —	—	—, —, —	—	—, —, —	—
6a	—, —, —	—	—, —, —	—	—, —, —	—
9a	24, 21, 18	40	—, —, —	—	—, —, —	—
9b	22, 19, 13	80	22, 19, 15	40	9, —, —	>160
10a	21, 18, 12	80	—, —, —	—	—, —, —	—
10b	—, —, —	—	24, 20, 18	80	13, —, —	160
12a	—, —, —	—	12, —, —	160	—, —, —	—
15a	24, 21, 18	80	—, —, —	—	—, —, —	—
15b	11, —, —	>160	—, —, —	—	15, 12, —	160
Itraconazole	18, 11, —	160	21, 19, 15	80	12, —, —	>160

Zone of inhibition was measured in mm at concentration of 160, 80, and 40 μg mL⁻¹.
MIC (minimum inhibitory concentrations) were measured in μg mL⁻¹.
Control drug.