Table of Contents Author Guidelines Submit a Manuscript
Journal of Chemistry
Volume 2015, Article ID 593738, 7 pages
Research Article

Reaction of Nitrilimines with Pyruvaldehyde Hydrazones: Synthesis and Antimicrobial Evaluation of Some New 1,2,4-Triazole Derivatives

Department of Chemistry, Faculty of Applied Science, Al-Aqsa University of Gaza, P.O. Box 4051, Gaza 76888, State of Palestine

Received 2 December 2014; Accepted 14 February 2015

Academic Editor: Sevgi Kolaylı

Copyright © 2015 Hany M. Dalloul. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new series of 1,3,4,5,5-pentasubstituted-1,2,4-triazoles (4a–j, 6a–j) have been synthesized by the 1,3-dipolar cycloaddition of suitable nitrilimines 2 to pyruvaldehyde (2-oxopropanal) hydrazones having (COPh, COOMe, COOEt, Me/Me, and Me/Ph) groups 3 and 5. Both analytical and spectroscopical data of all the synthesized compounds are in full agreement with the proposed structures. The microbial features of the synthesized compounds were studied by a known method.